Journal article
Differential associations of mentally-active and passive sedentary behaviours and physical activity with putative cognitive decline in healthy individuals and those with bipolar disorder: Findings from the UK Biobank cohort
E Ringin, DW Dunstan, RS McIntyre, N Owen, M Berk, SL Rossell, M Hallgren, TE Van Rheenen
Mental Health and Physical Activity | Published : 2023
Abstract
Objective: Physical activity confers protection against age-related cognitive dysfunction, but less is known about whether cognition is impacted by sedentary behaviour, specifically its mentally-active and passive forms. Both physical inactivity and sedentary behaviour are highly prevalent in bipolar disorder (BD), yet if and how they relate to the disorder's cognitive symptoms remains unclear. In this study, we explored whether individual variation in physical activity and sedentary behaviour was directly associated with cognition and/or moderated the extent of decrements in cognitive performance occurring as a function of age in people with BD versus psychiatrically-healthy controls. Metho..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was conducted using the UK Biobank Resource under application number 60698. We acknowledge the efforts of the UK Bio-bank research team and thank all UK Biobank participants for agreeing to volunteer for this research. TVR was supported by an NHMRC Early Career Fellowship (GNT1088785) and a Dame Kate Campbell Fellowship from the University of Melbourne. MB was supported by a NHMRC Senior Principal Research Fellowship and Leadership 3 Investigator grant (1156072 and 2017131). SLR was supported by a NHMRC Senior Research Fellowship (GNT1154651). DD (GNT1078360), and NO (GNT1003960) were supported by NHMRC Senior Research Fellowships and the Victorian Operational Infrastructure Support (OIS) Program.